故事紧随着大毒枭巴勃罗·埃斯科巴的死亡之后，缉毒局将目标转向强大的卡利集团，虽然毒品市场在美国以及其他地方的不断壮大，出人意料的是卡利集团的领导人Gilberto Rodriguez Orejuela 宣布在6个月后放弃可卡因业务，专注于合法商业利益。而该决定在卡利集团内部引起了不同的反应。
CBS已续订《犯罪心理：穿越国界》第二季。
《犯罪心理：穿越国界 Criminal Minds: Beyond Borders》为《犯罪心理》的衍生剧，主要围绕FBI探员如何帮助国外居住的美国公民解决问题而展开。Gary Sinise：饰演Jack Garrett，在FBI待了20年，刚刚被指派负责这个部门。Tyler James Williams：饰演队中的技术分析员Monty，是个讨喜而又聪明的角色，平常在家工作，他对陷入困境的家庭以事无巨细的方式处理，协助队伍找到被遗留的线索，以及找到远在海外的真凶。Daniel Henney：Matt Simmons，不仅是一位在国外长大的军人还是一个居家好男人，喜欢探索和融入不同的文化，最重要的是他的侧写能力对整个团队致为关键。
Small Town, Big Story has started filming on location in Ireland under a UK Equity contract and follows goings-on in Drumbán, a rural village of rattled misfits. When a major Hollywood production rolls into town, a spotlight is thrown on a secret that has been kept hidden since the eve of the Millennium. Hendricks (Mad Men) is playing Wendy Patterson, a local girl done good as a hot-shot television producer, who returns to her hometown from LA with the Hollywood production in tow, while House of the Dragon’s Considine is local doctor and pillar of the community Seamus Proctor.
The detectives investigate a multiple homicide at a fast food restaurant; an addict gives his baby daughter to a drug dealer as collateral on an overdue loan; Internal Affairs reopens the Kirkendall case.
